Insilico Medicine used artificial intelligence to develop rentosertib, a drug for chronic lung disease, and early trial data suggests it may also reduce biological markers of aging. The findings come with major caveats: the sample size was small, the drug hasn't been tested in healthy people, and the "aging clocks" used to measure results are scientifically debated.

• Rentosertib reduced biological aging markers across six different AI-based "aging clocks" in a clinical trial, according to results published in Nature Biotechnology.
• The drug was originally developed for idiopathic pulmonary fibrosis (IPF) and has only been tested in sick patients, not healthy ones, so anti-aging claims remain speculative.
• The study has significant limitations: small sample size, unproven reliability of aging clock measurements, and the drug is still years away from regulatory approval even for its primary lung disease indication.

The New York Times asked artists in their 80s to describe the best and worst parts of that milestone. Bob Dylan offers his reflections but declines to give any advice to the president.

• Bob Dylan, now in his 80s, told the NYT the best part of the milestone is not caring what people think anymore and following his instincts.
• His stated downside was simply routine physical aches and stiffness, without further elaboration.
• Asked for advice for the president, Dylan declined to answer.
• Other octogenarian artists in the NYT series echoed a mix of sharper priorities and declining stamina, but all kept creating.

Recent data reveal that dementia prevalence at ages 70, 75, 80 and above has fallen compared to several decades ago. In fact, today’s 90-year-olds face less than half the dementia risk of those in 1984. This shift points to progress in prevention and treatment of age-related cognitive decline.

• Dementia prevalence has fallen across every age bracket studied (70, 75, 80+) compared to several decades ago
• 90-year-olds today face less than half the dementia risk of 90-year-olds in 1984 (under 15% vs. roughly one in three)
• Better education, blood pressure/cholesterol control, diabetes treatment, and healthier lifestyles are cited as the likely drivers

Embracing social connections has been a key factor in the longevity of the author's parents, who are both in their 90s. Despite not adhering to popular wellness trends, their warm interactions with strangers and active social lives have contributed significantly to their health and happiness.

• Benjamin Emanuel lived to 92 and Marsha is still thriving at 92, without meditation, step-tracking, or strict diets
• Their habit of warmly engaging strangers (patients, people met while traveling) seems to have been a bigger health factor than conventional wellness trends
• Emanuel, drawing on his own longevity research, argues casual social connection may matter more for health than diet or supplements