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Unlike alcohol or caffeine, THC stores in fat and organs and can affect inflammation and immune response long after the high ends. With stronger products and more frequent use, researchers are just starting to map out these lasting effects.
- THC is fat-soluble, so it stores in fatty tissue and organs and leaks back into the bloodstream over days or weeks, prolonging its effects well past the high.
- Modern concentrates exceeding 80% THC combined with daily or multiple-times-daily use mean tissues stay continuously loaded with the compound.
- Sustained THC exposure is linked to altered cytokine production, changed white-blood-cell activity, and mild chronic inflammation.
- Heavy use is associated with reduced infection resistance in animal studies and blunted vaccine responses and gut-immune shifts in humans.