The article claims AI agents can autonomously handle repetitive admin work—data entry, billing, insurance claims—for small businesses, freeing owners to serve more customers and improve work-life balance. It uses Lassie, deployed in over 700 medical practices and saving up to 190 hours of labor per month, as proof, and outlines the technical, regulatory, and go-to-market challenges in building and scaling these systems.

a16z led a $35 million Series A for Lassie, which builds AI agents to handle billing, insurance claims, payroll and other back‐office work for dental practices. The founders spent months in dental offices mapping workflows and have already onboarded 700 practices, cutting errors and saving 250,000 labor hours a year. Lassie plans to expand beyond dental into broader small-business automation.

Founders from the Department of Government Efficiency built SpecialOS, an AI-driven platform that automates tasks in Main Street service industries. Their first target is eldercare via Figure Health, where they’ve acquired a Texas provider, plan to open-source billing claims, and use efficiencies to boost nurse pay.

a16z led Westmag’s seed round to create a domestic motor and actuator manufacturer, tackling U.S. supply-chain reliance on Chinese parts amid tighter drone regulations. Founders David Hansen and Jordan Sanders have set up a semi-automated factory in South San Francisco and are scaling production for defense and robotics customers.

This page lists 15,494 open roles across 773 companies backed by a16z, filtered to show positions in the Speedrun department. Users can sort and search by company, role, skill, or location to find relevant job opportunities.

This piece argues that the core driver of growth-stage venture returns is the founder’s ability to spot and act on non-obvious tech opportunities indefinitely. VCs succeed by finding those rare, high-growth founders, giving them freedom and resources, and staying “in the car” for as long as needed.

Andreessen Horowitz has led a $55 million Series A round in Town, an AI-powered personal assistant that integrates with tools like email, calendar, Slack and docs to learn your workflow and proactively suggest or execute tasks. Founded by ex-Plaid/Dropbox CTO Jean-Denis Greze and ex-Google/Dropbox product lead Tony, Town aims to turn raw AI intelligence into practical leverage by holding deep, ongoing context and automating follow-ups, scheduling and other messy operational work.

This essay breaks down the term “world model” by tracing it to the POMDP perception-action loop and identifying its key components—renderers, simulators, planners, and their connecting loop. It shows how different AI fields project parts of this loop to build spatial and temporal understanding beyond language models.

Anne Neuberger argues that U.S. national security now depends on technology and that allies want to move beyond buyer-seller deals to co-develop AI, cybersecurity, and supply chain solutions. She traces tech’s evolution from Cold War state programs to today’s fragmented, geopoliticized landscape and urges building a shared foundation with partners to counter modern threats.

a16z has rebranded its Investor Relations arm as Global Partnerships to connect founders and LPs with sovereign, institutional, and strategic capital worldwide. The team will broker cross-border deals, engage governments and large investors, and help startups scale internationally from day one.

a16z is rolling out a structured program to help its growth-stage portfolio enter key international markets by adapting its US playbooks for regions like Japan, Korea, the Middle East, Europe, and Latin America. The firm will open new offices, leverage its talent and go-to-market teams, and build localized networks to guide founders through market-specific strategies rather than ad-hoc deals.

Andreessen Horowitz is launching initiatives to deepen partnerships with allied nations, support its portfolio companies’ international growth, and attract new strategic investors. They’ve appointed Anne Neuberger to lead global technology and policy efforts, Raghu Raghuram to help growth companies scale abroad, and Jen Kha to build overseas partnerships, while continuing to fund top startups worldwide.

The article shows U.S. office visits remain at about 70% of pre-pandemic levels, driving high vacancy rates and a flight to newer buildings. It also highlights research linking remote work—not AI—to rising youth unemployment, explores AI uptake among small employer firms versus solopreneurs, and details how emerging biotechs now lead in clinical trials and drug approvals.

Rillet’s AI-native ERP processes transactions as they happen, cutting manual month-end entries to under 1% and turning the traditional close into a daily routine. Data from 56 early adopters show nearly all entries auto-posted, though B2B and multi-entity firms still need more human judgment.

The article argues that companies are increasingly recording every meeting by default to feed AI systems the living context of their culture, decisions, and conversations. This shift turns unstructured voice data into a searchable, structured system of record that boosts individual productivity and executive oversight, making meeting recording inevitable.

The article uses charts to show a modest uptick in US manufacturing—driven mainly by AI machinery—while factories and non-AI equipment remain underbuilt. It also highlights a spike in canned cocktails, the rise of zero-click search driven by AI summaries, and increased volatility across public SaaS stocks.

The article breaks down how SpaceX ties Elon Musk’s pay to two massive goals—a self-sustaining Mars colony of one million people and orbiting data centers generating 100 terawatts—and then “works backward” through Starship, Starlink, Falcon 9 and lunar plans to show how each layer funds and enables the next. It also links Musk’s vision to Iain M. Banks’s Culture novels and lays out the energy, robotics, AI and launch-capacity prerequisites for a trillion-dollar, post-Earth civilization.

a16z is launching a small, stage-matched community for finance leaders, with cohorts of eight CFOs meeting six times over a year. Each session mixes practical workshops—on planning, forecasting, AI tools and scaling finance teams—with candid peer discussions to build trust and lasting support networks.

The article argues that AI will revolutionize drug discovery long before it can streamline clinical development, creating an abundance of candidate molecules but leaving patient trials as the main constraint. As discovery becomes commoditized and more assets target the same biology, real value will hinge on predictive toxicity, clinical efficacy, and strategic trial design.

Convey lets non-technical teams build AI “teammates” by walking through processes on screen and turning them into versioned, testable programs that run reliably. a16z led Convey’s $38M Series A after its agents logged over 1.1 million work hours at NBCUniversal, TelevisaUnivision and others, freeing up hundreds of hours weekly on reporting and ad ops.

a16z led Telepatia’s $33 million Series A to back its AI-native clinical platform in Latin America. The system, now live in 25+ hospital networks serving 14 million patients, blends AI documentation, decision support, and virtual medical staff to boost protocol adherence from 84% to 99% and prevent 60,000 errors.

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Andreessen Horowitz and angel investors have seeded Monitoring the Situation (MTS), a media startup that streams live interviews and analysis of tech, business, politics, and culture on X. MTS aims to replicate CNN’s rolling-news concept online by hosting experts and main characters of the moment to decode events as they unfold.

a16z has announced a significant $15 billion fundraising round, bringing its total assets under management to over $90 billion. The article delves into the firm’s history, investment strategies, and its approach to venture capital, emphasizing its unique positioning and the skepticism it has faced over the years.