Aliisa Rosenthal, who previously led sales at OpenAI, has transitioned to venture capital by joining Acrew Capital as a general partner. After three years at OpenAI, where she played a significant role in launching products like DALL·E and ChatGPT, she saw an opportunity in VC while engaging with various AI startups. Her experience in scaling OpenAI's enterprise sales team made the move appealing, allowing her to impact multiple startups instead of just one. Rosenthal emphasizes the importance of building a sustainable competitive advantage, or moat, for AI startups. Specialization is one strategy she suggests, as is leveraging the concept of "context." By developing a dynamic context layer—information that AI systems use to remember and adapt during interactions—startups can differentiate themselves from larger competitors like OpenAI. She also believes there’s a market for cost-effective AI models that may not top performance benchmarks but still offer valuable applications. Her approach to finding promising startups includes tapping into her network from OpenAI, which has grown substantially over the past decade. Many former colleagues have launched successful ventures, raising significant funds. Rosenthal aims to invest in startups that create innovative applications, particularly those that improve efficiency for enterprise users. There's still a gap in understanding AI's potential within enterprises, presenting opportunities for new applications and companies.